Although TNF-α inhibitors can be used to treat pustular psoriasis and dermatomyositis, they have also been reported to induce amyopathic dermatomyositis and polymyositis.[4,5] Herein, we report a case of psoriasis in a patient following treatment with Etanercept, who exhibited an increase in creatine kinase (CK) and a decline in muscle strength. This evidence concerns the gene TNF and psoriasis.