Surprisingly, up to 50% of RPL cases lack a clear underlying cause.[2] However, certain factors such as genetic disorders, uterine pathologies, endocrine dysfunctions, autoimmune diseases, and environmental influences have been commonly associated with RPL.[2] Recent studies have shed light on the potential involvement of insulin resistance, a metabolic condition characterized by impaired insulin action, in the development of this obstetric complication.[3]. Here, INS is linked to Insulin resistance.