GCG and diabetes mellitus: It emphasizes that DM can impair the protective effects of ischemic preconditioning, increasing susceptibility to MI/R injury.[18] The third most cited article, “Cardioprotective and vasodilatory actions of GLP-1 receptor are mediated through both GLP-1 receptor-dependent and -independent pathways,” shows that GLP-1 enhances coronary flow and reduces cellular damage after MI/R injury through an NO-cGMP-dependent mechanism.[19]