AKT1 and obesity due to melanocortin 4 receptor deficiency: Keyword bursts serve as predictive indicators for emerging research trends and can unveil potential hotspots within the research field.[16,17] As shown in Figure 7C, the keyword with high citation bursts in diabetic MI/R injury is “insulin,” “mortality,” “in vivo,” “nitric oxide synthase,” “nitric oxide,” “Akt,” “activated protein kinase,” “myocardial ischemia reperfusion injury,” “reperfusion,” “GLP-1,” and “cell death.” Among the top 25 keywords still in a burst state are “myocardial ischemia reperfusion injury,” “autophagy,” “obesity,” and “cell death.”