These effects are maximized when GLP-1 receptor agonists are administered in combination with insulin.[48] In diabetic hearts, liraglutide enhances survival following myocardial infarction by activating prosurvival pathways.[14] Additionally, exenatide increases myocardial PKA activity and reduces myocardial infarct size in db/db mice.[49]. Here, INS is linked to myocardial infarction.