RGS3 and inborn mitochondrial metabolism disorder: Furthermore, we observed signals in important genes associated with ASD pathways (Table 3), such as RGS3 in Cluster 24, encoding a regulator of G protein signaling [66]; NUBPL in Cluster 25, previously associated with mitochondrial disease [73]; and OR13F1 in Cluster 8, encoding an olfactory receptor [36].