These were initially termed cancer-associated satellite transcript (CAST) bodies; however, HSat2 RNA bodies are also seen in other disease contexts, where we call them satellite transcript (SATT) bodies, and sequester different regulatory factors, including CTCF (CCCTC-binding factor) (122), EIF4A3 (eukaryotic translation initiation factor 4A3), and ADAR1 (adenosine deaminase RNA 1) (141), leading to further dysregulation of cell homeostasis and gene expression. The gene discussed is EIF4A3; the disease is cancer.