CD4 and amyotrophic lateral sclerosis: The use of immunohistochemistry in the ALS rat model hSODG93A characterised inflammatory processes in the rodent brain as a CD4 + lymphocyte-dominated (T-helper cells) infiltration in the midbrain-interbrain-region, whereas CD8 + cell infiltrates (cytotoxic T-cells) were more restricted to the brainstem region and the blood-brain-barrier was impaired in areas of T-cell infiltrations [67].