It is also likely that there will not be just one treatment for each class, but rather that defining a cancer as either YAPon or YAPoff will direct you towards a subset of drugs - e.g., kinase or YAP/TEAD inhibitors for YAPon cancers and BCL2, XPO1, NAMPT or epigenetic inhibitors for YAPoff cancers. The gene discussed is BCL2; the disease is cancer.