YAP1 and cancer: In YAPon cancers, YAP/TAZ-TEAD promote expression of cell cycle genes [14,16–18,46,48]; however, in YAPoff solid cancers, ectopic YAP does not induce cell cycle genes and instead up-regulates extracellular matrix, cytoskeletal, and adhesion genes (e.g., YAPAd genes) [14,23,24,30].