In cell lines from many solid YAPoff cancers, including SCLC [14,19–21], retinoblastoma [14,21,22], NEPC [14], NE pancreatic cancer [14], NE breast [14], lung carcinoid [23], and MCC [24], forced YAP and/or TAZ expression impairs cell growth. This evidence concerns the gene YAP1 and retinoblastoma.