YAP1 and cancer: Furthermore, in human patients, binding sites for AP1 transcription factors, key YAP/TEAD partners in YAPon cancers [14,46,47], are the top hypermethylated transcription factor motif in SCLC (YAPoff) compared with lung adenocarcinoma (YAPon) [55], and in mouse models, AP1 sites were hyperaccessible in lung adenocarcinoma compared with SCLC [56].