Whether these differences represent distinct mechanisms of regulation of YAP and TAZ (i.e., TAZ is regulated by DNA methylation, whereas YAP is not), differences between cancer types (i.e., multiple myeloma vs. SCLC), or cell line/sample-to-sample variation remains to be determined, particularly since YAP and TAZ regulation were not tested together in these studies. The gene discussed is WWTR1; the disease is AL amyloidosis.