Unlike in YAPoff blood cancers, the tumor suppressor function of YAP and TAZ in YAPoff solid cancers is dependent on TEADs (Figure 2C) [14,24,30] the same mediators of YAP/TAZ oncogenic activity in YAPon cancers (Figure 2A) [26–29]. Here, WWTR1 is linked to hematopoietic and lymphoid system neoplasm.