This suggests that the regulation of YAP in these SCLC cell lines may be distinct from that of the H660 NEPC line [44], although work on a wider range of models from these, and other YAPoff cancers, is required to deduce if these differences represent variability between different YAPoff cancers, or simply sample-to-sample variability. The gene discussed is YAP1; the disease is small cell lung carcinoma.