MYC and small cell lung carcinoma: Furthermore, in a genetically engineered mouse model of SCLC, over-expression of Myc drives temporal evolution from a YAPoff-to-YAPon state [156], and in a well-established in vitro model of SCLC chemotherapy resistance, the H69AR model, cells convert from a non-adherent to adherent morphology [157,158], which is accompanied by induction of YAP [20,159].