While there are rare instances of deletion/mutation of YAP in YAPoff cancers, for example, ~ 10% of multiple myeloma possess YAP deletions [36], YAP and TAZ are not commonly deleted in cancer [57], so this does not appear to be the primary mechanism of YAP/TAZ silencing in YAPoff cancers. The gene discussed is WWTR1; the disease is plasma cell myeloma.