It is important for future work to uncover the mechanism(s) by which LRRK2 contributes to mtDNA damage accumulation in PD, as targeting the LRRK2-mitochondria-mtDNA connection could lead to treatments for addressing LRRK2 and mitochondrial dysfunction, and subsequent DA neuron degeneration, in both LRRK2 PD and iPD. The gene discussed is LRRK2; the disease is Parkinson disease.