LRRK2 and Parkinson disease: Despite these positive findings, it should be noted that basal mitophagy was not altered in homozygous G2019S LRRK2 KI HEK293 cells, in G2019S LRRK2 PD patient fibroblasts, or in R1441C LRRK2 IPSC-derived DA neurons compared with controls [91,114,154].