Grade 3 non-hematologic DLTs at DL7 included elevated ALT, AST, and GGT in one patient; dose-limiting grade 3 nausea, vomiting, and dehydration occurred in another patient who was hospitalized with these symptoms and died of a pulmonary embolism; the death was considered possibly related to treatment (Table 2, Supplementary Table S5). Here, GPT is linked to pulmonary embolism.