If an RBC transfusion is deemed necessary during an acute episode of DHTR due to poor clinical or biological tolerance of anaemia (e.g., total Hb < 3 g/dL and/or organ failures), it should be carried out after consultation with a paediatric or adult expert center of SCD and may have to be accompanied by immunological therapies (e.g., corticosteroids, immunoglobulins, Eculizumab, Rituximab). The gene discussed is GSTM1; the disease is anemia.