If an RBC transfusion is deemed necessary during an acute episode of DHTR due to poor clinical or biological tolerance of anaemia (e.g., total Hb < 3 g/dL and/or organ failures), it should be carried out after consultation with a paediatric or adult expert center of SCD and may have to be accompanied by immunological therapies (e.g., corticosteroids, immunoglobulins, Eculizumab, Rituximab). This evidence concerns the gene GSTM1 and Schnyder corneal dystrophy.