To investigate the involvement of GSDMD in AP, we first evaluated the expression levels of GSDMD and its downstream activating molecules interleukin‐1beta (IL‐1β), interleukin‐18 (IL‐18), and caspase‐1 in serum samples from 15 patients with mild AP (MAP), 15 patients with moderately severe AP (MSAP), 30 patients with SAP, and 30 control participants. Here, IL18 is linked to alkaline phosphatase measurement.