GSDMD and alkaline phosphatase measurement: Notably, IL‐10 is an anti‐inflammatory cytokine that inhibits the secretion of pro‐inflammatory cytokines by monocytes and macrophages.[24] Previous studies have shown the elevation of IL‐10 in the serum of patients with AP to inhibit the excessive secretion of pro‐inflammatory cytokines, which reflects a protective mechanism of the body.[25, 26, 27] Therefore, we speculate that GSDMD knockout reduces the release of pro‐inflammatory cytokines, leading to the feedback downregulation of IL‐10 expression.