Consistently, the levels of serum inflammatory factors such as IL‐1β, IL‐18, IL‐6, IL‐10, IL‐12p70, and TNF‐α in the GSDMD−/− AP group were lower than those in the WT AP group, suggesting that GSDMD may play a role in promoting inflammation in AP. This evidence concerns the gene TNF and alkaline phosphatase measurement.