GSDMD and alkaline phosphatase measurement: reported that interleukin‐37 prevents acinar cell pyroptosis in AP.[14] Moreover, GSDMD is closely associated with the formation of neutrophil extracellular traps in SAP.[15] In addition, the NLRP3/caspase‐1/GSDMD pyroptotic pathway is involved in the disruption of the intestinal mucosal barrier in SAP rats, whereas free total rhubarb anthraquinones protects the intestinal mucosal barrier by inhibiting this pathway.[16] Presently, various small‐molecule compounds, including necrosulfonamide[17] and disulfiram,[18] have been found to inhibit GSDMD activity and prevent pyroptosis.