Before co‐incubation with macrophages, the acinar cells were stimulated with 0.001 mm CCK for 30 min to simulate a cellular pancreatitis model.[19] Thereafter, GSDMD−/− or control macrophages were co‐incubated with freshly prepared pancreatic acinar cells for 6 h, and the levels of inflammatory cytokines in the cell culture supernatant were detected (Figure 7A). The gene discussed is GSDMD; the disease is pancreatitis.