Furthermore, Mon activated ferroptosis in HCC cells, characterized by elevated levels of Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA), alongside a reduction in glutathione (GSH) content and downregulation of nuclear factor E2‐related factor 2 (Nrf2), heme oxygenase‐1 (HO‐1), and glutathione peroxidase 4 (Gpx‐4). Here, HMOX1 is linked to hepatocellular carcinoma.