Hypertension, a key component of metabolic syndrome, is a well-recognized risk factor for severe COVID-19, likely through dysregulation of the renin-angiotensin-aldosterone system, altered immune responses, gastrointestinal disturbances, and increased inflammation; all of which might have prolonged effects on organs, including lungs, heart, and brain, and contribute to persistent symptoms (38). This evidence concerns the gene REN and metabolic syndrome.