APOE and infection: This lack of ApoE-dependent phenotype suggests that either elevated plasma cholesterol and triglycerides have no effect on MHV68 infection of an intact host (in contrast to that observed for acute influenza and SARS-CoV-2 infections in high-fat diet-fed mice [72, 73]) or that ApoE engagement of corresponding receptors in the presence of increased circulating lipids may be required to alter parameters of chronic MHV68 infection.