This phenotypic heterogeneity is also seen for other cardiomyopathy-related genes (e.g. MYH7) where different mutations in the same gene lead to a wide spectrum of cardiomyopathy phenotypes like DCM, hypertrophic cardiomyopathy (HCM), and LVNC.74 The differences amongst Cre-driver KO models are presumably the consequence of variable temporal and spatial promoter—and hence Cre-recombinase—activities. The gene discussed is MYH7; the disease is cardiomyopathy.