Despite the prominent role of endothelial dysfunction in these vascular disorders, the majority of these studies focus on PRDM16's role in other compartments of the vascular wall where PRDM16 is more prominently expressed, including the SMC layer79 and the perivascular adipose tissue (PVAT).80 The latter undergoes browning in response to vascular injury, with beneficial effects on vascular inflammation and pathological vascular remodelling. Here, PRDM16 is linked to endothelial dysfunction.