In an elastase-induced AAA mouse model, SMC-specific Prdm16 KO mice showed aggravated AAA formation compared to their WT littermates (Figure 4I), while knockdown of Prdm16 in cultured SMCs induced inflammation and apoptosis.85 Mechanistically, PRDM16 drives expression of ECM components, while suppressing Adam12, encoding an ECM-remodelling proteinase. The gene discussed is ADAM12; the disease is triple-A syndrome.