PRDM16 and neoplasm: sPRDM16 displays increased expression in leukaemic cells and has been extensively associated with leukaemogenesis, indicating that the PR domain of PRDM16 functions as an important repressor of cell division, tumour initiation, and growth.2,4–7 The full PRDM16 protein is encoded by 17 exons and includes, in addition to the N-terminal PR domain, the following functional domains: (i) a proline-rich domain, (ii) an SAM-binding motif PLDLS domain, and (iii) 2 zinc finger (ZF) regions, i.e. ZF1 and ZF2 containing 7 and 3 ZFs, respectively (Figure 1A and B).