Humans heterozygous for p.S91C or p.E93G point mutations within the prodomain of BMP4 show congenital birth defects and/or enhanced predisposition to colorectal cancer (Bakrania et al., 2008; Lubbe et al., 2011; Suzuki et al., 2009; Weber et al., 2008). Here, BMP4 is linked to colorectal cancer.