Of note, α1β1 integrin heterodimer co‐localizes with the amyloid β precursor protein in axons and around astrocytes during Alzheimer's disease plaque formation (Yamazaki et al. 1997), suggesting a potential role for NDR2 in amyloidosis‐induced neuronal deficits and synaptic aging via integrin regulation. This evidence concerns the gene STK38L and Alzheimer disease.