PTHrP: parathyroid hormone-related protein; 1,25-(OH)2D3: 1,25-dihydroxyvitamin D; RANKL: receptor activator of nuclear factor kappa-Β ligand; IL-6: interleukin-6; MIP-1α: macrophage inflammatory protein-1α; TNF-α: tumor necrosis factor-alpha; Ca: calcium; DLBCL: diffuse large B-cell lymphoma; NHL: non-Hodgkin lymphoma. The gene discussed is PTHLH; the disease is diffuse large B-cell lymphoma.