For example, exosomes with circPACRGL released by colorectal cancer cells can promote colorectal cancer proliferation, migration, and invasion by regulating the miR-142-3p/miR-506-3p-TGF-β1 axis (91). By releasing exosomes, tumor cells can regulate the immunosuppressive function of MDSCs, thereby affecting tumorigenesis and progression. The gene discussed is TGFB1; the disease is colorectal cancer.