Recent studies have shown that IFN treatment for PV can achieve a high rate of CHR and molecular response, some patients’ bone marrow biopsy can significantly improve or even return to normal, a few patients with significantly reduced JAK2V617F VAF can maintain long-term stability of the disease after discontinuing IFN treatment, thus making IFN a significant treatment option for PV patients (3, 21). Here, IFNA1 is linked to acquired polycythemia vera.