Previous TCGA database analysis has revealed the potential molecular mechanism of HER2 overexpression promoting tumor development, and the relevant experimental results have been verified: the ERBB signaling pathway where HER2 gene is located is closely related to cell proliferation and migration, and its amplification may drive tumor progression through activation of the downstream MAPK and PI3K-AKT pathways (12). The gene discussed is AKT1; the disease is neoplasm.