Knockdown of BCKDK reduces NSCLC cell proliferation in vitro and induces apoptosis by inhibiting glycolysis while increasing oxidative phosphorylation and ROS levels, suggesting that BCKDK may promote NSCLC proliferation and could have clinical significance in treating NSCLC patients (Wang Y. et al., 2021). The gene discussed is BCKDK; the disease is non-small cell lung carcinoma.