LAT1 is a transporter of BCAAs, and studies have found that hypoxia upregulates the mRNA and protein levels of LAT1 and BCAT1 in human glioblastoma (GBM) cell lines through the binding of HIF-1α and HIF-2α to the intron of the BCAT1 gene. The gene discussed is EPAS1; the disease is glioblastoma.