Furthermore, tanshinone IIA (Tan IIA) (Feng et al., 2020a), derived from traditional Chinese medicine Salvia miltiorrhiza (Danshen), robustly suppresses TGF-β1/Smad signaling, inhibiting collagen I, collagen III, and α-SMA expression, effectively reducing fibrosis severity in a silica-induced pulmonary fibrosis model using Wistar rats. This evidence concerns the gene ACTA1 and pulmonary fibrosis.