Concurrently, advanced target deconvolution techniques like thermal proteome profiling (TPP) allow global analysis of thermal stability shifts across 7,000+ proteins (Savitski et al., 2014), as demonstrated by the discovery that CDC42 inhibitors stabilize β-catenin/E-cadherin complexes to suppress renal fibrosis—a mechanism with cross-organ relevance for IPF (Hu et al., 2024). Here, CDH1 is linked to idiopathic pulmonary fibrosis.