In 8-week-old C57BL/6 mice, the infiltration of neutrophils and macrophages in lung tissue induced by radiation was significantly reduced. The expression levels of inflammatory cytokines (such as TIMP-1, CXCL1, MCP-1, MIP-2 and IL-1Ra) in pleural effusion were reduced (Dong et al., 2022; Wu et al., 2021). The gene discussed is CXCL1; the disease is Pleural effusion.