Inhibits multiple signaling pathways (TGF-β/Smad, PI3K-Akt-mTOR, MAPK), reducing fibrosis in bleomycin-induced mouse models. EZY-1 inhibited the phosphorylation of ERK and p38MAPK, preventing the progression of idiopathic pulmonary fibrosis by inhibiting the MAPK signaling pathway activated by TGF-β. This evidence concerns the gene AKT1 and pulmonary fibrosis.