Furthermore, S1PR1 is involved in the neuroinflammatory response in a variety of diseases, such as Alzheimer’s disease (Zhu et al., 2023), experimental autoimmune encephalomyelitis (Tsai et al., 2016; Zheng et al., 2023; Uchi et al., 2023; Garris et al., 2013), cancer-induced neuroinflammation (Grenald et al., 2017), and COVID-19 – induced neurological dysfunction (Pan et al., 2021). The gene discussed is S1PR1; the disease is Alzheimer disease.