For example, Israel et al. (2023) research demonstrated that by conjugating microRNA (miRNA) and antisense RNA with a D-configured peptide, the Low-Density Lipoprotein Receptor-Related Protein-1 (LRP-1) transcytosis pathway could be effectively leveraged for targeted delivery across the BBB, achieving efficient and neuron-selective delivery in AD mouse models. The gene discussed is LRP1; the disease is Alzheimer disease.