In a large cohort study involving 14,976 breast cancer patients, post-diagnostic statin use was associated with a significantly reduced risk of breast cancer-specific mortality (adjusted HR 0.74, 95% CI 0.63–0.86), with more pronounced protective effects observed in estrogen receptor-positive (ER+) patients, postmenopausal women, and those with advanced-stage disease (Scott et al., 2023). The gene discussed is ESR1; the disease is breast cancer.