HIF1A and alcoholic fatty liver disease: Additionally, KEGG pathway analysis showed that genes differentially expressed between the WD group and the Chow group were predominantly enriched in pathways like metabolic pathways, carbon metabolism, biosynthesis of amino acids, chemical carcinogenesis-reactive oxygen species, non-alcoholic fatty liver disease, thermogenesis, and HIF-1 signaling pathway, etc. (Supplementary Figure S1B).