Besides, there are studies reported that Cpn intervention could not only regulate lipid metabolism-related proteins and reduce inflammatory responses to improve fatty liver in HFD-induced obese mice but also ameliorate hepatic steatosis in mice with diet-induced nonalcoholic steatohepatitis (Gong et al., 2021; Lan et al., 2021). The gene discussed is CPN1; the disease is fatty liver disease.