To elucidate the potential anti-inflammatory role of GO@GSH-FA in ischemia-induced cellular damage, we quantitatively assessed the levels of key proinflammatory cytokines, namely Tumor Necrosis Factor-α (TNF-α) and, Interleukin-1β (IL-1β) in SH-SY5Y cells subjected to oxygen-glucose deprivation and reoxygenation (OGD/R) and treated with GO@GSH-FA. This evidence concerns the gene TNF and ischemia.