MAP2K1 and neurodegenerative disease: RAD23B is involved in DNA repair and neurodegeneration in neurodegenerative diseases such as amyotrophic lateral sclerosis (Wang et al., 2019; Schludi et al., 2017), while MAP2K1 plays a critical role in synaptic plasticity and neurotransmission in addiction and psychiatric disorders (Alasmari et al., 2020; O'Connell et al., 2023).