Sixteen prognostic signature genes (AIF1, ALOX5AP, CAPG, CYBA, FCER1G, FCGR2A, FPR1, HLA-DMA, LAPTM5, MSR1, S100A11, SERPINA1, SERPINB1, SLC11A1, TNFRSF1B, and TYROBP) were identified for the construction of a prognostic signature for glioma. This evidence concerns the gene TYROBP and central nervous system cancer.