MDH1 and Alzheimer disease: Consensus hub genes were defined as genes selected by ≥2 algorithms and intersected with PPI network-derived candidates, resulting in seven pyroptosis-AD hub genes: CHMP2A (the charged multivesicular body protein 2A), EGFR (epidermal growth factor receptor), FOXP3 (forkhead box P3), HSP90B1 (heat shock protein 90 beta family member 1), MDH1 (malate dehydrogenase 1), METTL3 (methyltransferase 3), and PKN2 (serine/threonine protein kinase C-related kinase 2) (Figure 4F and Supplementary Table S4).