PKN2 and Alzheimer disease: Then, qPCR analysis of hippocampal tissues further confirmed differential expression: Mdh1 was significantly downregulated (p = 0.0157), while Egfr (p = 0.0115), Pkn2 (p = 0.0067), and Hsp90b1 (p = 0.0038) were upregulated in the AD mice (Figures 7D–G).