Similarly, 4 weeks of treadmill exercise (30 min/day at 15 months/min or 10 months/min, 40 min/day at 3 days/week) increased the expression of CoxI-V and TH, upregulated Parkin and PINK1 in the SNpc, decreased methamphetamine-induced rotations, and improved abnormal gait in PD rats (Chuang et al., 2017; Ferreira et al., 2020). This evidence concerns the gene PRKN and Parkinson disease.