Mitophagy deficits observed in neurodegenerative pathologies like Alzheimer’s disease are similarly mitigated by exercise: In APP/PS1 transgenic Alzheimer’s disease mice, 12 weeks of treadmill exercise (5 months/min for 5 min, 8 months/min for 5 min, 12 months/min for 30 min, and 5 months/min for 5 min, 45 min/day, 5 days/week) significantly increased hippocampal expression of the mitophagy-related proteins Parkin and LC3II and improved ultrastructure of mitochondria (Zhao et al., 2020). This evidence concerns the gene PRKN and early-onset autosomal dominant Alzheimer disease.