In contrast, TH expression was elevated in the SNpc of MPP+-induced PD mice following a 6 weeks treadmill exercise (12 months/min, 60 min/day, 5 days/week), along with restored mitochondrial CoxI-V expression, increased mitochondrial density, and elevated levels of phosphorylated Drp1Ser637, which was reduced by MPP+ treatment (Jang et al., 2018b). The gene discussed is COX4I1; the disease is Parkinson disease.