IRE-containing mRNAs have been found in a variety of other proteins recently, including α-synuclein in Parkinson disease (Wilkinson and Pantopoulos, 2014), α-hemoglobin stabilizing protein (dos Santos et al., 2008), and Alzheimer’s amyloid precursor protein (APP) (Cho et al., 2010; Rogers et al., 2002). This evidence concerns the gene APP and Parkinson disease.