MAPT and early-onset autosomal dominant Alzheimer disease: The development of extracellular β-amyloid (Aβ) peptide aggregation, intracellular hyperphosphorylated tau protein buildup in neurofibrillary formations, and an increased brain iron content are the hallmarks of Alzheimer’s disease (AD) (Olufunmilayo and Holsinger, 2023).