DKK4 and ablepharon macrostomia syndrome: Jia et al. distinguished between AMS-susceptible and AMS-resistant individuals through the analysis of plasma cytokine profiles at low altitude, pinpointing four key cytokines, i.e., IGFBP-6, SAA1, Dkk4, and IL-17RA, out of 75 differentially expressed ones as potential AMS susceptibility predictors [37].