Further study found that manganese treatment caused gene expression changes of multiple autophagy pathways, while mitochondrial dynamics and function-related genes were not significantly changed, Mn induced damage to autophagy and protein aggregation in dopaminergic neurons can be weakened by the inhibition of Drp1, and autophagy damage and mitochondrial dysfunction are two prominent features of neurodegenerative diseases, thus inhibiting Drp1 to improve mitochondrial function has become an attractive therapeutic target [124]. Here, DNM1L is linked to neurodegenerative disease.