On the other hand, decreased proliferation in another hormone-dependent BC cell line T47D after therapy with higher concentrations of genistein (25 μM to 100 μM) was not associated with p-JNK expression; however, a decrease in phosphorylated p90RSK (a downstream effector protein of the MAPK pathway) was found (after treatment with 100 μM) [114]. Here, MAPK8 is linked to breast cancer.