MAPK8 and breast cancer: The hypothesis that EGCG may improve the effect of microtubules-interfering chemotherapeutics is supported by another study by Luo et al. where EGCG counteracted paclitaxel-induced upregulation of GRP78 expression and increased paclitaxel-induced p-JNK both in murine triple-negative 4T1 mammary cancer cells (20 μM) and BALB/c mice carrying 4T1 transplants (30 mg/kg/day i.p.