Similar to the effects of hyperglycemia on bone marrow, obese adipose tissue releases S100A8/S100A9 and stimulates IL-1β secretion from bone marrow progenitor cells via activation of TLR4/MyD88 signaling and NLRP3 inflammasomes, promoting the expansion of monocytes and neutrophils (92). Here, S100A8 is linked to Hyperglycemia.