In the overwhelming majority of tauopathies, the initiator of disease is anyway not amyloid-β, but either physical trauma resulting most likely in axonal disruption due to shearing forces such as in TBI (10), a range of genetic disorders leading to Tau pathology as a secondary event, or Tau itself [e.g., Tau pathogenic mutations resulting in a subset of FTD (11). Here, MAPT is linked to hereditary disease.