Hypoalbuminemia, or low levels of ALB (often defined as < 3.5–4.0 g/dL or ≤ 3.5 mmol/L), is a well-established risk factor for increased morbidity and mortality (32, 39) and has also been associated with mortality of sepsis; it is modifiable by ALB infusion. The gene discussed is ALB; the disease is Sepsis.