The results showed that HAMD score (OR = 1.158, 95% CI = 1.091-1.229, p < 0.001), punishment score (OR = 1.117, 95% CI = 1.039-1.201, p = 0.003), and Log IL-6 level (OR = 5.041, 95% CI = 1.137-22.344, p = 0.033) were independent correlates of appetite loss in adolescents with MDD. This evidence concerns the gene IL6 and major depressive disorder.