The treatment with QFY reversed the low level of GnRH in male 3×Tg-AD mice (Figure 7B, P=0.0390, F=1.324) and the FSH (Figure 7F, P<0.0001, F=19.85), LH (Figure 7I, P=0.0012) in female 3×Tg-AD mice. Here, GNRH1 is linked to Alzheimer disease.