Modern research has found that QFY can inhibit the TLR4/NF-κB pathway, thereby reducing neuroinflammation (59), the activation of the TLR4/NF-κB pathway is associated with anxiety and depression-like symptoms (60, 61), therefore, it is inferred that QFY has therapeutic potential for depressive symptoms. Here, NFKB1 is linked to major depressive disorder.