However, no significant association was observed between the remaining clinical variables, particularly HAMD scores, and either CpG locus or cognitive function, as the statistical p-values were greater than 0.05.To further understand the relationship between the methylation level of the GRIN2B gene and cognitive impairment, we conducted a bias-corrected correlation analysis, controlling for confounders such as age, age of onset, duration of disease and years of education. This evidence concerns the gene GRIN2B and Cognitive impairment.