In this study, we detected the expression level of IL-13, the initiating factors that overexpressed in CRSwNP, and explored its downstreaming factor mTOR/p70S6K1 pathway-related molecules, found that mTOR/p70S6K1 pathway exerts its physiological function mainly through post-translational phosphorylation of proteins because p-mTOR and p-p70S6K1 expression levels are clearly upregulated compared to mTOR and p70S6K1. Here, RPS6KB1 is linked to chronic rhinosinusitis with nasal polyps.