In this study, the expression of mTOR/p70S6K1 pathway-related molecules, basal cell marker P63, cell proliferation marker Ki67, and cell cycle-related factors cyclin E1, CDK2 were upregulated after IL-13 stimulation of nasal epithelial cells including HNESPCs, the distribution pattern of cilia cell was disordered and messy, which was similar to the expression pattern in CRSwNP tissues. The gene discussed is CDK2; the disease is chronic rhinosinusitis with nasal polyps.