RPS6KB1 and chronic rhinosinusitis with nasal polyps: In this study, the expression of mTOR/p70S6K1 pathway-related molecules, basal cell marker P63, cell proliferation marker Ki67, and cell cycle-related factors cyclin E1, CDK2 were upregulated after IL-13 stimulation of nasal epithelial cells including HNESPCs, the distribution pattern of cilia cell was disordered and messy, which was similar to the expression pattern in CRSwNP tissues.