While Zhang et al. was examining the function and mechanism of lncRNA MEG3 in melatonin-mediated NPC action, they discovered that the melatonin-regulated MEG3-miR-15a-5p-PGC-1α/SIRT1 pathway may prevent IL-1β-induced inflammation and NPC apoptosis (Zhang C. et al., 2023). The gene discussed is SIRT1; the disease is nasopharyngeal carcinoma.