Despite their many differences, the two insulin-expressing cancer cell populations shared strong expression of other beta cell and glucose/insulin-related genes (such as IAPP, PCSK2, NKX2-2, ABCC8, ALDOB, ALDOC, and SLC30A8) as well as chromogranin and secretogranin family genes (CHGA (ENSCAFG00000024864), CHGB, SCG2, SCG3, SCG5, and SCGN) (Fig. 3E, Supplementary Tables 4–5). This evidence concerns the gene PCSK2 and cancer.