NKX2-2 and cancer: Despite their many differences, the two insulin-expressing cancer cell populations shared strong expression of other beta cell and glucose/insulin-related genes (such as IAPP, PCSK2, NKX2-2, ABCC8, ALDOB, ALDOC, and SLC30A8) as well as chromogranin and secretogranin family genes (CHGA (ENSCAFG00000024864), CHGB, SCG2, SCG3, SCG5, and SCGN) (Fig. 3E, Supplementary Tables 4–5).