AKT1 and cancer: Comparing the DEGs from one insulin-expressing cluster to the other, KEGG pathway analysis showed an enrichment of genes in several pathways well-known for their deregulation in cancer, such as MAPK, mTOR, PI3K-AKT, Notch, Wnt, and p53 signalling pathways as well as cellular senescence and apoptosis pathways (Supplementary Table 7, Fig. 3B).