LGALS3 and cancer: Due to the structure of the non-reducing disaccharide motif, they are close to human milk oligosaccharides lacto-N-tetraose and lacto-N-neotetraose, known as strong ligands of Gal-3.20 Moreover, poly-LacNAc motifs are known to be present on the surface of many cancer cells to be recognized by galectins.