HMGB3 and neoplasm: Zhang et al. (2021) reported that the secretion of the extracellular vesicle high-mobility group box 3 (HMGB3) by nasopharyngeal carcinoma cells could promote tumor metastasis by inducing angiogenesis, providing a new target for tumor metastasis. Furthermore, the role of platelets in the TME cannot be overlooked, as they enhance the metastatic ability of tumor cells by releasing proangiogenic factors and cytokines (Huong et al., 2019).