ANGPT2 and kaposiform hemangioendothelioma: In our previous review (Ji et al., 2020), we reported the upregulation of ANG-2 expression in patients with kaposiform hemangioendothelioma, suggesting that the reason may be the activation of TIE-2 induced by ANG-2, triggering Akt/mTOR signalling, which is primarily mediated by the PI3K alpha catalytic subunit (PIK3CA) in endothelial cells (Kim I. et al., 2000).