PFKFB3 and cancer: Research by Gu et al. (2017) indicated that knockdown of PFKFB3 not only inhibited the invasiveness of CNE2 human nasopharyngeal carcinoma cells but also suppressed the upregulation of E-cadherin while downregulating the surface expression of vimentin and N-cadherin, emphasizing the important role of PFKFB3 in cancer cell proliferation and invasiveness and suggesting that it is a potential clinical biomarker for angiogenesis and a therapeutic target for inhibiting angiogenesis.