We further measured the level of seven cytokines from the plasma of TB patients, performed a comparative analysis between time points, and observed that IL-6 and IFN-γ were the most significantly higher levels of cytokines, which play an important role in the acute phase response against Mtb, while later they may potentiate tissue damage and induce other pathological pathways (31, 32). This evidence concerns the gene IL6 and tuberculosis.