SPP1 and posterior cortical atrophy: What’s more, our research suggests that the enhancement of the CSF1-CSF1R and IL34-CSF1R signaling pathways might be an important reason for the enhanced angiogenic capabilities of SPP1+ macrophages resulting in metastasis and poor prognosis in PCa patients with high infiltration levels of both FAP+ fibroblasts and SPP1+ macrophages.