Through analyzing the relationship between rs12979860 polymorphism and IFN response, our results showed that rs12979860 TT variant produced lower levels of IL-29, IL-28A, IL-28B, IFNβ1 and CXCL10 (ISGs of IL-29) in the absence of virus infection or in response to Cal04 or PR8 virus infection, while having no effect on the expression of ISGs-Mx1 (Figures 5A–F, Supplementary Figures 3A–F). This evidence concerns the gene IFNB1 and viral infectious disease.